Assay Detail
Functional
CHEMBL750437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.58 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59986 | — | — | 1 | 5.05 |
| CHEMBL262769 | — | — | 1 | 4.44 |
| CHEMBL430497 | TEBANICLINE | 2.0 | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59986 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL262769 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL430497 | TEBANICLINE | EC50 | = | 56000.0 | nM | 4.25 |