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Assay Detail

CHEMBL750438

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Holladay MW, Dart MJ, Lynch JK.
J Med Chem (1997) 40 : 4169 -4194
PubMed 9435889 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 4.58 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6623 EPIBATIDINE 1 5.46
CHEMBL59986 1 5.05
CHEMBL335712 1 4.71
CHEMBL497939 CYTISINICLINE 3.0 1 4.15
CHEMBL3 NICOTINE 4.0 1 4.08
CHEMBL134752 DIMETHYLPHENYLPIPERAZINIUM 1 4.02
CHEMBL274525 ABT-418 1 -
CHEMBL667 ACETYLCHOLINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6623 EPIBATIDINE EC50 = 3500.0 nM 5.46
CHEMBL59986 EC50 = 8900.0 nM 5.05
CHEMBL335712 EC50 = 19600.0 nM 4.71
CHEMBL497939 CYTISINICLINE EC50 = 71000.0 nM 4.15
CHEMBL3 NICOTINE EC50 = 83000.0 nM 4.08
CHEMBL134752 DIMETHYLPHENYLPIPERAZINIUM EC50 = 95000.0 nM 4.02
CHEMBL274525 ABT-418 EC50 = 264000.0 nM -
CHEMBL667 ACETYLCHOLINE EC50 = 155000.0 nM -