Assay Detail

CHEMBL750461

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Compound was tested for its inhibitory activity against Noradrenaline receptor

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.

Quiñones-Torrelo C, Sagrado S, Villanueva-Camañas RM, Medina-Hernández MJ.
J Med Chem (1999) 42 : 3154 -3162
PubMed 10447960 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	6	7.67	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL72	DESIPRAMINE	4.0	1	8.70
CHEMBL445	NORTRIPTYLINE	4.0	1	8.05
CHEMBL629	AMITRIPTYLINE	4.0	1	7.39
CHEMBL415	CLOMIPRAMINE	4.0	1	7.34
CHEMBL11	IMIPRAMINE	4.0	1	7.34
CHEMBL1628227	DOXEPIN	4.0	1	7.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL72	DESIPRAMINE	IC50	=	2.0	nM	8.70
CHEMBL445	NORTRIPTYLINE	IC50	=	9.0	nM	8.05
CHEMBL629	AMITRIPTYLINE	IC50	=	41.0	nM	7.39
CHEMBL415	CLOMIPRAMINE	IC50	=	46.0	nM	7.34
CHEMBL11	IMIPRAMINE	IC50	=	46.0	nM	7.34
CHEMBL1628227	DOXEPIN	IC50	=	65.0	nM	7.19