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Assay Detail

CHEMBL750470

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Functional
Cytotoxic activity against NUGC gastric cancer cell line
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Stomach
Cell Type NUGC
Confidence 1 — Organism
Curated By Expert

Target

NUGC (CHEMBL614207)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives.
Chern JH, Shia KS, Chang CM, Lee CC, Lee YC, Tai CL, Lin YT, Chang CS, Tseng HY.
Bioorg Med Chem Lett (2004) 14 : 1169 -1172
PubMed 14980658 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.01 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL17289 CHS-828 1.0 1 7.60
CHEMBL16928 1 6.67
CHEMBL17429 1 6.54
CHEMBL278064 1 6.41
CHEMBL17007 1 6.39
CHEMBL17376 1 6.03
CHEMBL278676 1 5.96
CHEMBL17364 1 5.91
CHEMBL417088 1 5.89
CHEMBL17029 1 5.75
CHEMBL280435 1 5.56
CHEMBL417264 1 5.52
CHEMBL17077 1 5.50
CHEMBL16678 1 5.48
CHEMBL16532 1 5.47
CHEMBL17137 1 5.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL17289 CHS-828 IC50 = 25.0 nM 7.60
CHEMBL16928 IC50 = 214.0 nM 6.67
CHEMBL17429 IC50 = 288.0 nM 6.54
CHEMBL278064 IC50 = 386.0 nM 6.41
CHEMBL17007 IC50 = 406.0 nM 6.39
CHEMBL17376 IC50 = 926.0 nM 6.03
CHEMBL278676 IC50 = 1101.0 nM 5.96
CHEMBL17364 IC50 = 1245.0 nM 5.91
CHEMBL417088 IC50 = 1282.0 nM 5.89
CHEMBL17029 IC50 = 1780.0 nM 5.75
CHEMBL280435 IC50 = 2756.0 nM 5.56
CHEMBL417264 IC50 = 3037.0 nM 5.52
CHEMBL17077 IC50 = 3124.0 nM 5.50
CHEMBL16678 IC50 = 3344.0 nM 5.48
CHEMBL16532 IC50 = 3354.0 nM 5.47
CHEMBL17137 IC50 = 3448.0 nM 5.46