Assay Detail
Binding
CHEMBL750485
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Binding affinity for nAChR with [3H]-nicotine in rat alpha4 beta2 membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-4 (CHEMBL307) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-Azidoimidacloprid and an acyclic analogue as candidate photoaffinity probes for mammalian and insect nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.83 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97343 | 5-AZIDOIMIDACLOPRID | — | 1 | 8.36 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97343 | 5-AZIDOIMIDACLOPRID | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL406819 | IMIDACLOPRID | Ki | = | 50.0 | nM | 7.30 |