Assay Detail
Functional
CHEMBL750550
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Compound was tested for potency against human myeloma 8226 cells (40 fold resistant to doxorubicin).
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1,4-disubstituted anthracene antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.30 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287188 | — | — | 1 | 5.52 |
| CHEMBL125698 | — | — | 1 | 5.40 |
| CHEMBL332153 | — | — | 1 | 5.40 |
| CHEMBL125332 | — | — | 1 | 5.30 |
| CHEMBL333690 | — | — | 1 | 5.30 |
| CHEMBL22696 | — | — | 1 | 5.17 |
| CHEMBL25336 | BISANTRENE | 3.0 | 1 | 5.04 |
| CHEMBL121864 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287188 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL125698 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL332153 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL125332 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL333690 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL22696 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL25336 | BISANTRENE | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL121864 | — | IC50 | > | 10000.0 | nM | - |