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Assay Detail

CHEMBL750570

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis.
Barn DR, Bom A, Cottney J, Caulfield WL, Morphy JR.
Bioorg Med Chem Lett (1999) 9 : 1329 -1334
PubMed 10340623 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.98 9.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL286053 1 9.27
CHEMBL27161 1 8.85
CHEMBL27432 1 8.74
CHEMBL13470 SNC-80 1 8.70
CHEMBL24035 3 8.39
CHEMBL27779 1 8.26
CHEMBL281471 1 8.24
CHEMBL416930 1 8.00
CHEMBL27944 1 7.94
CHEMBL27579 1 7.54
CHEMBL27578 1 7.38
CHEMBL28443 1 7.16
CHEMBL28097 1 6.92
CHEMBL283070 1 6.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL286053 IC50 = 0.54 nM 9.27
CHEMBL27161 IC50 = 1.4 nM 8.85
CHEMBL27432 IC50 = 1.8 nM 8.74
CHEMBL13470 SNC-80 IC50 = 2.0 nM 8.70
CHEMBL24035 IC50 = 4.1 nM 8.39
CHEMBL27779 IC50 = 5.5 nM 8.26
CHEMBL281471 IC50 = 5.8 nM 8.24
CHEMBL24035 IC50 = 8.0 nM 8.10
CHEMBL24035 IC50 = 8.0 nM 8.10
CHEMBL416930 IC50 = 10.0 nM 8.00
CHEMBL27944 IC50 = 11.4 nM 7.94
CHEMBL27579 IC50 = 29.0 nM 7.54
CHEMBL27578 IC50 = 42.0 nM 7.38
CHEMBL28443 IC50 = 70.0 nM 7.16
CHEMBL28097 IC50 = 120.0 nM 6.92
CHEMBL283070 IC50 = 845.0 nM 6.07