Assay Detail
Functional
CHEMBL750575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist potency at cloned human delta-opioid receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of the first N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid delta receptor antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.68 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329470 | — | — | 1 | 8.74 |
| CHEMBL94741 | — | — | 1 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329470 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL94741 | — | IC50 | = | 2.4 | nM | 8.62 |