Assay Detail
Functional
CHEMBL750687
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Inhibition of mammalian H-Ras processing in NIH 3T3 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.08 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138719 | — | — | 1 | 7.70 |
| CHEMBL431828 | — | — | 1 | 6.70 |
| CHEMBL54044 | — | — | 1 | 6.00 |
| CHEMBL141513 | — | — | 1 | 5.30 |
| CHEMBL349270 | — | — | 1 | 4.70 |
| CHEMBL336266 | — | — | 1 | - |
| CHEMBL344687 | — | — | 1 | - |
| CHEMBL165159 | — | — | 1 | - |
| CHEMBL433873 | — | — | 1 | - |
| CHEMBL342449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138719 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL431828 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL54044 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL141513 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL349270 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL336266 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL344687 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL165159 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL433873 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL342449 | — | IC50 | > | 100000.0 | nM | - |