Assay Detail
Functional
CHEMBL750696
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Concentration that produced 50% of the maximal response in intracellular calcium mobilization in the NCI-H345 cells.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H345 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Minor structural differences in Boc-CCK-4 derivatives dictate affinity and selectivity for CCK-A and CCK-B receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.13 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143025 | — | — | 1 | 7.33 |
| CHEMBL3142898 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143025 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3142898 | — | EC50 | = | 120.0 | nM | 6.92 |