Assay Detail
Functional
CHEMBL750699
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Ability to block CCK-8-induced calcium mobilization in NCI-H345 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H345 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Amino acid-derived piperidides as novel CCKB ligands with anxiolytic-like properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.23 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432599 | — | — | 1 | 8.70 |
| CHEMBL320154 | — | — | 1 | 6.94 |
| CHEMBL418987 | — | — | 1 | 6.66 |
| CHEMBL420658 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432599 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL320154 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL418987 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL420658 | — | IC50 | = | 251.0 | nM | 6.60 |