Assay Detail
Functional
CHEMBL750707
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In vitro cytotoxic activity against nonsmall cell lung carcinoma (NCI-H460) cells assayed by inhibition of [3H]-labeled thymidine incorporation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.71 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 9.89 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.85 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.11 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.18 |
| CHEMBL138287 | — | — | 1 | 4.80 |
| CHEMBL138636 | — | — | 1 | 4.75 |
| CHEMBL140357 | — | — | 1 | 4.39 |
| CHEMBL139865 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL138287 | — | IC50 | = | 15709.0 | nM | 4.80 |
| CHEMBL138636 | — | IC50 | = | 17997.0 | nM | 4.75 |
| CHEMBL140357 | — | IC50 | = | 40310.0 | nM | 4.39 |
| CHEMBL139865 | — | IC50 | = | 137590.0 | nM | - |