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Assay Detail

CHEMBL750982

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

P2X purinoceptor 4 (CHEMBL2104)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Purine and pyrimidine (P2) receptors as drug targets.
Jacobson KA, Jarvis MF, Williams M.
J Med Chem (2002) 45 : 4057 -4093
PubMed 12213051 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 5.46 6.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL339386 1 6.31
CHEMBL14249 ADENOSINE TRIPHOSPHATE 2.0 1 6.30
CHEMBL336208 1 6.00
CHEMBL339385 DIADENOSINE TETRAPHOSPHATE 1 6.00
CHEMBL69234 1 5.00
CHEMBL335206 1 4.60
CHEMBL28324 1 4.00
CHEMBL223344 RB 2 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL339386 EC50 = 490.0 nM 6.31
CHEMBL14249 ADENOSINE TRIPHOSPHATE EC50 = 500.0 nM 6.30
CHEMBL336208 EC50 = 1000.0 nM 6.00
CHEMBL339385 DIADENOSINE TETRAPHOSPHATE EC50 = 1000.0 nM 6.00
CHEMBL69234 EC50 = 10000.0 nM 5.00
CHEMBL335206 EC50 = 25000.0 nM 4.60
CHEMBL28324 EC50 = 100000.0 nM 4.00
CHEMBL223344 RB 2 EC50 = 128000.0 nM -