Assay Detail
Functional
CHEMBL750986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Purine and pyrimidine (P2) receptors as drug targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.76 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337062 | — | — | 1 | 4.82 |
| CHEMBL130094 | — | — | 1 | 4.70 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | - |
| CHEMBL129841 | — | — | 1 | - |
| CHEMBL69234 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337062 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL130094 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL265502 | SURAMIN | EC50 | > | 100000.0 | nM | - |
| CHEMBL129841 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL69234 | — | EC50 | > | 10000.0 | nM | - |