Assay Detail
Binding
CHEMBL751028
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Inhibitory activity against neutral endopeptidase (NEP).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.69 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290698 | — | — | 1 | 9.00 |
| CHEMBL285619 | — | — | 1 | 8.30 |
| CHEMBL40028 | — | — | 1 | 7.85 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.52 |
| CHEMBL39384 | — | — | 1 | 6.77 |
| CHEMBL37052 | — | — | 1 | 6.60 |
| CHEMBL434208 | — | — | 1 | 6.39 |
| CHEMBL290332 | — | — | 1 | 6.19 |
| CHEMBL446393 | — | — | 1 | 6.14 |
| CHEMBL416234 | — | — | 1 | 6.07 |
| CHEMBL288837 | — | — | 1 | 6.02 |
| CHEMBL37542 | — | — | 1 | 5.92 |
| CHEMBL39887 | — | — | 1 | 5.89 |
| CHEMBL39828 | — | — | 1 | 5.68 |
| CHEMBL40168 | — | — | 1 | 5.60 |
| CHEMBL36753 | — | — | 1 | 5.39 |
| CHEMBL147847 | — | — | 1 | 5.24 |
| CHEMBL290868 | — | — | 1 | 5.21 |
| CHEMBL36382 | — | — | 1 | 5.20 |
| CHEMBL39777 | — | — | 1 | 5.20 |
| CHEMBL39714 | — | — | 1 | 5.19 |
| CHEMBL289150 | — | — | 1 | 5.17 |
| CHEMBL37078 | — | — | 1 | 5.16 |
| CHEMBL290256 | — | — | 1 | 5.07 |
| CHEMBL35995 | — | — | 1 | 5.01 |
| CHEMBL290304 | — | — | 1 | 5.00 |
| CHEMBL37456 | — | — | 1 | 5.00 |
| CHEMBL36809 | — | — | 1 | 4.97 |
| CHEMBL448098 | — | — | 1 | 4.96 |
| CHEMBL289638 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290698 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL285619 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL40028 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL39384 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL37052 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL434208 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL290332 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL446393 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL416234 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL288837 | — | IC50 | = | 948.0 | nM | 6.02 |
| CHEMBL37542 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL39887 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL39828 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL40168 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL36753 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL147847 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL290868 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL39777 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL36382 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL39714 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL289150 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL37078 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL290256 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL35995 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL37456 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL290304 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL36809 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL448098 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL289638 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL39997 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL287971 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL39812 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL417507 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL37861 | — | IC50 | = | 55000.0 | nM | 4.26 |