Assay Detail
Binding
CHEMBL751034
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Binding affinity towards cloned human Opioid receptor kappa 1 in CHO cell membranes.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
[Pro(3)]Dyn A(1-11)-NH(2): a dynorphin analogue with high selectivity for the kappa opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.43 | 10.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216640 | — | — | 1 | 10.13 |
| CHEMBL405190 | — | — | 1 | 9.82 |
| CHEMBL573214 | NORBINALTORPHIMINE | — | 1 | 9.44 |
| CHEMBL407389 | — | — | 1 | 8.57 |
| CHEMBL269377 | — | — | 1 | 7.19 |
| CHEMBL405097 | — | — | 1 | 7.03 |
| CHEMBL413729 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216640 | — | Ki | = | 0.074 | nM | 10.13 |
| CHEMBL405190 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL407389 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL269377 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL405097 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL413729 | — | Ki | = | 160.0 | nM | 6.80 |