Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL751101

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of neuraminidase of influenza A/PR/8/34(H1N1)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Neuraminidase (CHEMBL2051)
Type SINGLE PROTEIN
Organism Influenza A virus (A/Puerto Rico/8/1934(H1N1))

Publication

Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
Williams MA, Lew W, Mendel DB, Tai CY, Escarpe PA, Laver W, Stevens RC, Kim CU
Bioorg Med Chem Lett (1997) 7 : 1837 -1842
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.80 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL674 OSELTAMIVIR CARBOXYLATE -1.0 1 9.00
CHEMBL55921 1 8.74
CHEMBL432329 1 8.34
CHEMBL54479 1 7.66
CHEMBL51955 1 7.22
CHEMBL54758 1 6.89
CHEMBL53507 1 6.85
CHEMBL53049 1 6.65
CHEMBL298659 1 6.28
CHEMBL52195 1 5.85
CHEMBL53768 1 5.82
CHEMBL54806 1 5.70
CHEMBL53050 1 5.66
CHEMBL52862 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL674 OSELTAMIVIR CARBOXYLATE IC50 = 1.0 nM 9.00
CHEMBL55921 IC50 = 1.8 nM 8.74
CHEMBL432329 IC50 = 4.6 nM 8.34
CHEMBL54479 IC50 = 22.0 nM 7.66
CHEMBL51955 IC50 = 60.0 nM 7.22
CHEMBL54758 IC50 = 130.0 nM 6.89
CHEMBL53507 IC50 = 140.0 nM 6.85
CHEMBL53049 IC50 = 225.0 nM 6.65
CHEMBL298659 IC50 = 530.0 nM 6.28
CHEMBL52195 IC50 = 1400.0 nM 5.85
CHEMBL53768 IC50 = 1500.0 nM 5.82
CHEMBL54806 IC50 = 2000.0 nM 5.70
CHEMBL53050 IC50 = 2200.0 nM 5.66
CHEMBL52862 IC50 = 25000.0 nM 4.60