Assay Detail
Functional
CHEMBL751111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Purine and pyrimidine (P2) receptors as drug targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.32 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223344 | RB 2 | — | 1 | 6.44 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 5.85 |
| CHEMBL131890 | ATPGAMMAS | — | 1 | 5.82 |
| CHEMBL336208 | — | — | 1 | 5.82 |
| CHEMBL335206 | — | — | 1 | 4.00 |
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | 4.00 |
| CHEMBL129841 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223344 | RB 2 | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL131890 | ATPGAMMAS | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL336208 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL335206 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL129841 | — | EC50 | > | 10000.0 | nM | - |