Assay Detail
Functional
CHEMBL751122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of inward ion current elicited by ATP was determined at recombinant P2X3 receptor expressed in Xenopus oocytes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.61 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119416 | — | — | 1 | 7.60 |
| CHEMBL331250 | — | — | 1 | 7.44 |
| CHEMBL69727 | ISOPPADS | — | 1 | 7.13 |
| CHEMBL119180 | — | — | 1 | 6.89 |
| CHEMBL119235 | — | — | 1 | 6.85 |
| CHEMBL117766 | — | — | 1 | 6.84 |
| CHEMBL69234 | — | — | 1 | 6.62 |
| CHEMBL331358 | — | — | 1 | 6.48 |
| CHEMBL118007 | — | — | 1 | 6.32 |
| CHEMBL116926 | — | — | 1 | 6.32 |
| CHEMBL304765 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119416 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL331250 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL69727 | ISOPPADS | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL119180 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL119235 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL117766 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL69234 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL331358 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL118007 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL116926 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL304765 | — | IC50 | = | 58300.0 | nM | 4.23 |