Assay Detail
Binding
CHEMBL751261
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity determined against Opioid receptor delta 1 from human cloned receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.95 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 9.62 |
| CHEMBL2111838 | — | — | 1 | 7.56 |
| CHEMBL2111836 | — | — | 1 | 7.20 |
| CHEMBL127828 | — | — | 1 | 7.16 |
| CHEMBL127969 | — | — | 1 | 7.03 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.52 |
| CHEMBL2448130 | — | — | 1 | 6.36 |
| CHEMBL2111837 | — | — | 1 | 6.35 |
| CHEMBL124015 | — | — | 1 | 6.31 |
| CHEMBL2448128 | — | — | 1 | 6.26 |
| CHEMBL2448129 | — | — | 1 | 6.12 |
| CHEMBL440765 | U-69593 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL2111838 | — | Ki | = | 27.8 | nM | 7.56 |
| CHEMBL2111836 | — | Ki | = | 63.2 | nM | 7.20 |
| CHEMBL127828 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL127969 | — | Ki | = | 93.9 | nM | 7.03 |
| CHEMBL70 | MORPHINE | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL2448130 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL2111837 | — | Ki | = | 451.0 | nM | 6.35 |
| CHEMBL124015 | — | Ki | = | 494.0 | nM | 6.31 |
| CHEMBL2448128 | — | Ki | = | 544.0 | nM | 6.26 |
| CHEMBL2448129 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL440765 | U-69593 | Ki | > | 1000.0 | nM | - |