Assay Detail
Functional
CHEMBL751265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against neuronal nicotinic acetylcholine receptor (alpha3-betaX subunit) in IMR 32 cell line using 100 uM of (-)-nicotine as agonist
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | IMR 32 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Nicotinic acetylcholine receptor alpha3/betaX (CHEMBL2111384) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.48 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160950 | — | — | 1 | 6.16 |
| CHEMBL346301 | — | — | 1 | 6.10 |
| CHEMBL156204 | — | — | 1 | 6.10 |
| CHEMBL157250 | — | — | 1 | 6.05 |
| CHEMBL156502 | — | — | 1 | 5.96 |
| CHEMBL345206 | — | — | 1 | 5.90 |
| CHEMBL156049 | — | — | 1 | 5.82 |
| CHEMBL349544 | — | — | 1 | 5.77 |
| CHEMBL157188 | — | — | 1 | 5.70 |
| CHEMBL352018 | — | — | 1 | 5.63 |
| CHEMBL158834 | — | — | 1 | 5.63 |
| CHEMBL159136 | — | — | 1 | 5.54 |
| CHEMBL160624 | — | — | 1 | 5.47 |
| CHEMBL158162 | — | — | 1 | 5.32 |
| CHEMBL157135 | — | — | 1 | 5.29 |
| CHEMBL156048 | — | — | 1 | 5.29 |
| CHEMBL155909 | — | — | 1 | 5.24 |
| CHEMBL347133 | — | — | 1 | 5.21 |
| CHEMBL160766 | — | — | 1 | 5.20 |
| CHEMBL158944 | — | — | 1 | 5.20 |
| CHEMBL348275 | — | — | 1 | 5.19 |
| CHEMBL158529 | — | — | 1 | 5.16 |
| CHEMBL160447 | — | — | 1 | 5.16 |
| CHEMBL156452 | — | — | 1 | 5.14 |
| CHEMBL446684 | — | — | 1 | 5.12 |
| CHEMBL158331 | — | — | 1 | 5.10 |
| CHEMBL346981 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160950 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL346301 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL156204 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL157250 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL156502 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL345206 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL156049 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL349544 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL157188 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL352018 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL158834 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL159136 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL160624 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL158162 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL157135 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL156048 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL155909 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL347133 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL160766 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL158944 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL348275 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL158529 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL160447 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL156452 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL446684 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL158331 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL346981 | — | IC50 | = | 24700.0 | nM | 4.61 |