Assay Detail
Functional
CHEMBL751286
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In vitro antiproliferative activity against NCI-460 (human lung) cell line.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.99 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416056 | — | — | 1 | 6.62 |
| CHEMBL124072 | — | — | 1 | 6.41 |
| CHEMBL302234 | — | — | 1 | 6.37 |
| CHEMBL545295 | — | — | 1 | 6.28 |
| CHEMBL62253 | — | — | 1 | 6.28 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.23 |
| CHEMBL127852 | — | — | 1 | 6.21 |
| CHEMBL339948 | — | — | 1 | 6.15 |
| CHEMBL341035 | — | — | 1 | 6.01 |
| CHEMBL126087 | — | — | 1 | 5.92 |
| CHEMBL293898 | — | — | 1 | 5.91 |
| CHEMBL127997 | — | — | 1 | 5.89 |
| CHEMBL53856 | — | — | 1 | 5.82 |
| CHEMBL304428 | — | — | 1 | 5.79 |
| CHEMBL301515 | — | — | 1 | 5.61 |
| CHEMBL124620 | — | — | 1 | 5.59 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.50 |
| CHEMBL341110 | — | — | 1 | 5.18 |
| CHEMBL124033 | — | — | 1 | - |
| CHEMBL123777 | — | — | 1 | - |
| CHEMBL126922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416056 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL124072 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL302234 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL545295 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL62253 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL127852 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL339948 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL341035 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL126087 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL293898 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL127997 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL53856 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL304428 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL301515 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL124620 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL341110 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL124033 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL123777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126922 | — | IC50 | > | 10000.0 | nM | - |