Assay Detail
Functional
CHEMBL751336
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Inhibition of human NCI-H460 (lung) carcinoma cell proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.73 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.23 |
| CHEMBL338264 | — | — | 1 | 5.94 |
| CHEMBL332575 | — | — | 1 | 5.68 |
| CHEMBL126545 | — | — | 1 | 5.55 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.50 |
| CHEMBL421087 | — | — | 1 | 5.47 |
| CHEMBL127532 | — | — | 1 | - |
| CHEMBL338289 | — | — | 1 | - |
| CHEMBL340685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL338264 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL332575 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL126545 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL421087 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL127532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338289 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340685 | — | IC50 | > | 10000.0 | nM | - |