Assay Detail
Binding
CHEMBL751377
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The compound was tested in vitro for binding affinity for the norepinephrine transporter (NET) using competitive binding assay.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.34 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343369 | Rhenium complex | — | 1 | 8.14 |
| CHEMBL422290 | — | — | 1 | 7.79 |
| CHEMBL2079586 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343369 | Rhenium complex | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL422290 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL2079586 | — | IC50 | = | 834.0 | nM | 6.08 |