Assay Detail
Functional
CHEMBL751445
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Inhibition of LTB4-induced up-regulation of human neutrophil CD11b/CD18 integrin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.35 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292782 | — | — | 1 | 8.92 |
| CHEMBL129463 | — | — | 1 | 8.74 |
| CHEMBL340460 | — | — | 1 | 8.47 |
| CHEMBL129272 | — | — | 1 | 8.27 |
| CHEMBL88337 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292782 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL129463 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL340460 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL129272 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL88337 | — | IC50 | = | 47.0 | nM | 7.33 |