Assay Detail
Binding
CHEMBL751504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ouabain from dog kidney Na+/K+ ATPase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Sodium/potassium-transporting ATPase (CHEMBL2095186) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and quantitative structure-activity relationship of 17 beta-(hydrazonomethyl)-5 beta-androstane-3 beta,14 beta-diol derivatives that bind to Na+,K(+)-ATPase receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.63 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2068885 | — | — | 1 | 7.00 |
| CHEMBL2068930 | — | — | 1 | 6.70 |
| CHEMBL2068942 | — | — | 1 | 6.70 |
| CHEMBL2068992 | — | — | 1 | 6.60 |
| CHEMBL2068928 | — | — | 1 | 6.00 |
| CHEMBL2069000 | — | — | 1 | 5.70 |
| CHEMBL2068993 | — | — | 1 | 5.70 |
| CHEMBL2069002 | — | — | 1 | 5.20 |
| CHEMBL2068932 | — | — | 1 | 5.10 |
| CHEMBL2068931 | — | — | 1 | 4.70 |
| CHEMBL2068933 | — | — | 1 | 4.70 |
| CHEMBL2068997 | — | — | 1 | 4.60 |
| CHEMBL2069104 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2068885 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2068930 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2068942 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2068992 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL2068928 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2069000 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL2068993 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL2069002 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL2068932 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2068931 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2068933 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2068997 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL2069104 | — | IC50 | = | 31622.78 | nM | 4.50 |