Assay Detail
Binding
CHEMBL751507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Na+/K+ ATPase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Potassium-transporting ATPase alpha chain 2 (CHEMBL2933) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.51 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2093999 | ISTAROXIME | 2.0 | 1 | 6.70 |
| CHEMBL3137924 | — | — | 1 | 5.22 |
| CHEMBL3138258 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2093999 | ISTAROXIME | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3137924 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3138258 | — | IC50 | = | 25000.0 | nM | 4.60 |