Assay Detail
Functional
CHEMBL751659
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Inhibitory concentration required for 50% inhibition of antagonism towards opioid receptor delta 1 in [35S]GTP-gamma-S, binding assay in guinea pig caudate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.81 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611431 | — | — | 1 | 7.26 |
| CHEMBL611437 | — | — | 1 | 7.13 |
| CHEMBL611434 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611431 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL611437 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL611434 | — | IC50 | = | 920.0 | nM | 6.04 |