Assay Detail
Binding
CHEMBL751686
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Displacement of [3H]25-6981 from N-methyl-D-aspartate glutamate receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.07 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66626 | — | — | 1 | 8.47 |
| CHEMBL68831 | — | — | 1 | 8.42 |
| CHEMBL306899 | — | — | 1 | 8.42 |
| CHEMBL70918 | — | — | 1 | 8.31 |
| CHEMBL305195 | — | — | 1 | 8.25 |
| CHEMBL68881 | — | — | 1 | 8.12 |
| CHEMBL69967 | — | — | 1 | 8.12 |
| CHEMBL302292 | — | — | 1 | 7.95 |
| CHEMBL69429 | — | — | 1 | 7.82 |
| CHEMBL70615 | — | — | 1 | 7.70 |
| CHEMBL69219 | — | — | 1 | 7.65 |
| CHEMBL65954 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66626 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL68831 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL306899 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL70918 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL305195 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL68881 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL69967 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL302292 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL69429 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL70615 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL69219 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL65954 | — | Ki | = | 22.6 | nM | 7.65 |