Assay Detail
Functional
CHEMBL751706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism at NMDA receptor in mouse cortical wedge preparation expressed as concentration that inhibits by 50% depolarizations induced by 5 uM AMPA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.42 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110492 | — | — | 1 | 4.64 |
| CHEMBL267276 | TQX-173 | — | 1 | 4.34 |
| CHEMBL110664 | — | — | 1 | 4.28 |
| CHEMBL322916 | — | — | 1 | - |
| CHEMBL322440 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110492 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL267276 | TQX-173 | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL110664 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL322916 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL322440 | — | IC50 | = | 350000.0 | nM | - |