Assay Detail
Binding
CHEMBL751708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of [3H]MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of porcine brain membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate (NMDA) receptor subunit zeta 1 (CHEMBL3451) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.17 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280974 | — | — | 1 | 6.67 |
| CHEMBL28564 | ELIPRODIL | 2.0 | 1 | 6.56 |
| CHEMBL28565 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280974 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL28564 | ELIPRODIL | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL28565 | — | IC50 | = | 5100.0 | nM | 5.29 |