Assay Detail
Binding
CHEMBL751783
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Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Asymmetric synthesis of Boc-N-methyl-p-benzoyl-phenylalanine. Preparation of a photoreactive antagonist of substance P.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.56 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372071 | — | — | 1 | 8.96 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 8.80 |
| CHEMBL2372065 | — | — | 1 | 7.64 |
| CHEMBL2110361 | — | — | 1 | 7.25 |
| CHEMBL2372068 | — | — | 1 | 7.10 |
| CHEMBL2372070 | — | — | 1 | 6.96 |
| CHEMBL217406 | NEUROKININ A | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372071 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL235363 | SUBSTANCE P | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2372065 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2110361 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL2372068 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL2372070 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL217406 | NEUROKININ A | Ki | = | 630.0 | nM | 6.20 |