Assay Detail
Binding
CHEMBL751786
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Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.23 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295301 | — | — | 1 | 5.30 |
| CHEMBL297327 | — | — | 1 | 5.21 |
| CHEMBL444832 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295301 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL297327 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL444832 | — | IC50 | = | 6540.0 | nM | 5.18 |