Assay Detail
Functional
CHEMBL751806
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Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 )
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Purine and pyrimidine (P2) receptors as drug targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.20 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163419 | TNP-ATP | — | 2 | 9.05 |
| CHEMBL339386 | — | — | 1 | 7.10 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 6.47 |
| CHEMBL336208 | — | — | 1 | 6.46 |
| CHEMBL339385 | DIADENOSINE TETRAPHOSPHATE | — | 1 | 6.30 |
| CHEMBL131890 | ATPGAMMAS | — | 1 | 6.16 |
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | 6.13 |
| CHEMBL69234 | — | — | 1 | 5.77 |
| CHEMBL335206 | — | — | 1 | 5.06 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.83 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163419 | TNP-ATP | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL339386 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL336208 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL339385 | DIADENOSINE TETRAPHOSPHATE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL131890 | ATPGAMMAS | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL69234 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL335206 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL265502 | SURAMIN | EC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL1163419 | TNP-ATP | EC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | EC50 | > | 100000.0 | nM | - |