Assay Detail
Functional
CHEMBL751822
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Inhibition of hepatitis C virus in a cell based HCV replicon assay.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity study on a novel series of macrocyclic inhibitors of the hepatitis C virus NS3 protease leading to the discovery of BILN 2061.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 8.12 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39000 | — | — | 1 | 9.40 |
| CHEMBL40490 | — | — | 1 | 9.22 |
| CHEMBL288533 | — | — | 1 | 9.10 |
| CHEMBL290512 | — | — | 1 | 9.00 |
| CHEMBL43030 | — | — | 1 | 8.96 |
| CHEMBL430940 | — | — | 1 | 8.92 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 8.92 |
| CHEMBL289765 | — | — | 1 | 8.80 |
| CHEMBL41661 | — | — | 1 | 8.49 |
| CHEMBL288155 | — | — | 1 | 8.47 |
| CHEMBL287792 | — | — | 1 | 8.41 |
| CHEMBL40265 | — | — | 1 | 8.40 |
| CHEMBL291040 | — | — | 1 | 8.35 |
| CHEMBL431911 | — | — | 1 | 8.22 |
| CHEMBL288627 | — | — | 1 | 8.02 |
| CHEMBL288413 | — | — | 1 | 7.89 |
| CHEMBL291153 | — | — | 1 | 7.70 |
| CHEMBL39112 | — | — | 1 | 7.70 |
| CHEMBL431312 | — | — | 1 | 7.41 |
| CHEMBL295844 | — | — | 1 | 7.11 |
| CHEMBL41182 | — | — | 1 | 6.70 |
| CHEMBL289593 | — | — | 1 | 5.92 |
| CHEMBL216120 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39000 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL40490 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL288533 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL290512 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL43030 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL430940 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL289765 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL41661 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL288155 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL287792 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL40265 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL291040 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL431911 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL288627 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL288413 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL291153 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL39112 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL431312 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL295844 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL41182 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL289593 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL216120 | — | EC50 | = | 1900.0 | nM | 5.72 |