Assay Detail
Binding
CHEMBL751865
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Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.62 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132966 | RIVANICLINE | 2.0 | 1 | 7.60 |
| CHEMBL149808 | — | — | 1 | 5.64 |
| CHEMBL150421 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132966 | RIVANICLINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL149808 | — | Ki | = | 2285.0 | nM | 5.64 |
| CHEMBL150421 | — | Ki | ~ | 6000.0 | nM | - |