Assay Detail
Binding
CHEMBL751903
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In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IM-9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Importance of parallel vectors and "hydrophobic collapse" of the aligned aromatic rings: discovery of a potent substance P antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.24 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135022 | — | — | 1 | 9.77 |
| CHEMBL332644 | — | — | 1 | 8.70 |
| CHEMBL333308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135022 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL332644 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL333308 | — | Ki | > | 10000.0 | nM | - |