Assay Detail

CHEMBL751904

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Binding

In vitro inhibitory activity against human NK1 receptor was determined

ChEMBL ↗

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Target

Substance-P receptor (CHEMBL249) ↗

Open DB target context

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Substance-P receptor (CHEMBL249) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Substance-P receptor

CHEMBL249

Anchored from Assay target.

Protein identity Substance-P receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Substance-P receptor (CHEMBL249) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Spiro-piperidine non-peptide neurokinin-1 receptor antagonists

Armour D, Watson S, Pegg N, Heron N, Middlemiss D, Chan C, Cholerton T, Hubbard T, Vinader M, Davies H, Cocker J, Bays D, Ward P
Bioorg Med Chem Lett (1995) 5 : 2671 -2676
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.77	9.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL441225	CP-99994	—	1	9.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL441225	CP-99994	Ki	=	0.17	nM	9.77