Assay Detail
Binding
CHEMBL751909
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In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Photoactivatable analogues of a Substance P non-peptidic antagonist, for probing the antagonist binding site of the NK1 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.37 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441225 | CP-99994 | — | 1 | 9.60 |
| CHEMBL22360 | — | — | 1 | 9.40 |
| CHEMBL25492 | — | — | 1 | 9.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441225 | CP-99994 | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL22360 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL25492 | — | Ki | = | 0.7943 | nM | 9.10 |