Assay Detail
Binding
CHEMBL751994
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In vitro binding affinity against cloned human Opioid receptor kappa 1 expressed in HEK 293S cells
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.76 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 8.40 |
| CHEMBL3707089 | — | — | 1 | 7.51 |
| CHEMBL3707082 | — | — | 1 | 6.69 |
| CHEMBL3707102 | — | — | 1 | 6.19 |
| CHEMBL3707083 | — | — | 1 | 6.02 |
| CHEMBL3707103 | — | — | 1 | 5.92 |
| CHEMBL3707088 | — | — | 1 | 5.80 |
| CHEMBL2112841 | — | — | 1 | 5.77 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 5.77 |
| CHEMBL3707080 | — | — | 1 | 5.70 |
| CHEMBL2112842 | — | — | 1 | 5.53 |
| CHEMBL3707094 | — | — | 1 | 5.50 |
| CHEMBL2112843 | — | — | 1 | 5.47 |
| CHEMBL3707095 | — | — | 1 | 5.44 |
| CHEMBL3707101 | — | — | 1 | 5.27 |
| CHEMBL3707087 | — | — | 1 | 5.21 |
| CHEMBL3707076 | — | — | 1 | 5.16 |
| CHEMBL3707086 | — | — | 1 | 5.16 |
| CHEMBL3707075 | — | — | 1 | 5.14 |
| CHEMBL3706637 | — | — | 1 | 5.13 |
| CHEMBL3707097 | — | — | 1 | 5.13 |
| CHEMBL485 | CODEINE | 4.0 | 1 | 4.82 |
| CHEMBL3707085 | — | — | 1 | - |
| CHEMBL2112844 | — | — | 1 | - |
| CHEMBL3707084 | — | — | 1 | - |
| CHEMBL3707079 | — | — | 1 | - |
| CHEMBL3707090 | — | — | 1 | - |
| CHEMBL3707099 | — | — | 1 | - |
| CHEMBL2112838 | — | — | 1 | - |
| CHEMBL2112835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592 | LEVORPHANOL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3707089 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3707082 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3707102 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3707083 | — | IC50 | = | 961.0 | nM | 6.02 |
| CHEMBL3707103 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3707088 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2112841 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL70 | MORPHINE | IC50 | = | 1705.1 | nM | 5.77 |
| CHEMBL3707080 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL2112842 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL3707094 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2112843 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL3707095 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3707101 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL3707087 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3707076 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3707086 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL3707075 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3706637 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3707097 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL485 | CODEINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3706645 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707092 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707078 | — | IC50 | > | 6400.0 | nM | - |
| CHEMBL3706646 | — | IC50 | > | 9960.0 | nM | - |
| CHEMBL3707100 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL3707093 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707081 | — | IC50 | > | 9500.0 | nM | - |
| CHEMBL3706640 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707091 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707085 | — | IC50 | > | 4900.0 | nM | - |
| CHEMBL3707077 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL3707096 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112835 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112838 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707099 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL3707090 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707079 | — | IC50 | > | 5800.0 | nM | - |
| CHEMBL3707084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112844 | — | IC50 | > | 10000.0 | nM | - |