Assay Detail
Binding
CHEMBL752072
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The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.56 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554013 | — | — | 1 | 6.77 |
| CHEMBL543416 | — | — | 1 | 6.58 |
| CHEMBL2368616 | — | — | 1 | 6.46 |
| CHEMBL542949 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554013 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL543416 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2368616 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL542949 | — | IC50 | = | 390.0 | nM | 6.41 |