Assay Detail
Binding
CHEMBL752135
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Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.30 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285377 | — | — | 1 | 6.84 |
| CHEMBL281274 | — | — | 1 | 6.60 |
| CHEMBL26987 | — | — | 1 | 6.54 |
| CHEMBL27729 | — | — | 1 | 6.50 |
| CHEMBL283910 | — | — | 1 | 6.38 |
| CHEMBL27699 | — | — | 1 | 6.35 |
| CHEMBL280827 | — | — | 1 | 6.34 |
| CHEMBL447779 | — | — | 1 | 6.32 |
| CHEMBL26483 | — | — | 1 | 6.29 |
| CHEMBL418020 | — | — | 1 | 6.23 |
| CHEMBL26999 | — | — | 1 | 6.21 |
| CHEMBL283480 | — | — | 1 | 6.17 |
| CHEMBL28172 | — | — | 1 | 6.15 |
| CHEMBL283617 | — | — | 1 | 5.85 |
| CHEMBL27093 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285377 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL281274 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL26987 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL27729 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL283910 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL27699 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL280827 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL447779 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL26483 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL418020 | — | Ki | = | 587.0 | nM | 6.23 |
| CHEMBL26999 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL283480 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL28172 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL283617 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL27093 | — | Ki | = | 1800.0 | nM | 5.75 |