Assay Detail
Binding
CHEMBL752147
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Binding affinity against kappa opioid receptor from calf frontal cortex.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
14 beta-[(p-nitrocinnamoyl)amino]morphinones, 14 beta-[(p-nitrocinnamoyl)amino]-7,8-dihydromorphinones, and their codeinone analogues: synthesis and receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.41 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110238 | — | — | 1 | 8.35 |
| CHEMBL107157 | — | — | 1 | 8.30 |
| CHEMBL607068 | — | — | 1 | 8.18 |
| CHEMBL317035 | — | — | 1 | 7.97 |
| CHEMBL611136 | — | — | 1 | 7.92 |
| CHEMBL106189 | — | — | 1 | 7.59 |
| CHEMBL106876 | — | — | 1 | 7.57 |
| CHEMBL610885 | — | — | 1 | 7.41 |
| CHEMBL108794 | — | — | 1 | 7.17 |
| CHEMBL107164 | — | — | 1 | 6.94 |
| CHEMBL108406 | — | — | 1 | 6.90 |
| CHEMBL105827 | — | — | 1 | 6.79 |
| CHEMBL110666 | — | — | 1 | 6.77 |
| CHEMBL323430 | — | — | 1 | 6.74 |
| CHEMBL413258 | — | — | 1 | 6.56 |
| CHEMBL320060 | — | — | 1 | - |
| CHEMBL327111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110238 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL107157 | — | IC50 | = | 5.01 | nM | 8.30 |
| CHEMBL607068 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL317035 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL611136 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL106189 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL106876 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL610885 | — | IC50 | = | 39.1 | nM | 7.41 |
| CHEMBL108794 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL107164 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL108406 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL105827 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL110666 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL323430 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL413258 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL320060 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL327111 | — | IC50 | > | 1000.0 | nM | - |