Assay Detail
Binding
CHEMBL752204
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Binding affinity against Opioid receptor kappa 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.09 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290429 | CARFENTANIL | 2.0 | 1 | 7.37 |
| CHEMBL12391 | — | — | 1 | 7.24 |
| CHEMBL609147 | — | — | 1 | 7.20 |
| CHEMBL331883 | — | — | 1 | 6.91 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 6.71 |
| CHEMBL435380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290429 | CARFENTANIL | Ki | = | 43.1 | nM | 7.37 |
| CHEMBL12391 | — | Ki | = | 57.4 | nM | 7.24 |
| CHEMBL609147 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL331883 | — | Ki | = | 122.2 | nM | 6.91 |
| CHEMBL596 | FENTANYL | Ki | = | 196.5 | nM | 6.71 |
| CHEMBL435380 | — | Ki | > | 500.0 | nM | - |