Assay Detail
Binding
CHEMBL752207
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Displacement of [3H]U-69593 from Opioid receptor kappa 1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: variation of the delta address and its effects on affinity and selectivity for the delta opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.16 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 7.52 |
| CHEMBL316930 | — | — | 1 | 7.42 |
| CHEMBL317536 | — | — | 1 | 6.52 |
| CHEMBL329719 | — | — | 1 | 6.24 |
| CHEMBL98324 | — | — | 1 | 6.00 |
| CHEMBL95847 | — | — | 1 | 5.51 |
| CHEMBL318957 | — | — | 1 | 5.50 |
| CHEMBL95319 | — | — | 1 | 5.42 |
| CHEMBL319592 | — | — | 1 | 5.35 |
| CHEMBL319589 | — | — | 1 | - |
| CHEMBL441270 | — | — | 1 | - |
| CHEMBL95408 | — | — | 1 | - |
| CHEMBL329473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL316930 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL317536 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL329719 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL98324 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL95847 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL318957 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL95319 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL319592 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL319589 | — | Ki | > | 7000.0 | nM | - |
| CHEMBL441270 | — | Ki | > | 14000.0 | nM | - |
| CHEMBL95408 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL329473 | — | Ki | > | 7000.0 | nM | - |