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Assay Detail

CHEMBL752228

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Binding
Inhibition against neuronal Nitric Oxide Synthase(nNOS)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Nitric oxide synthase 1 (CHEMBL3048)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.
Lee Y, Martásek P, Roman LJ, Silverman RB.
Bioorg Med Chem Lett (2000) 10 : 2771 -2774
PubMed 11133088 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 5.53 8.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96680 1 8.20
CHEMBL262040 1 8.06
CHEMBL542185 1 6.40
CHEMBL94821 1 5.70
CHEMBL554323 1 5.52
CHEMBL545487 1 5.22
CHEMBL554676 1 5.10
CHEMBL542183 1 5.00
CHEMBL541572 1 4.92
CHEMBL543616 1 4.85
CHEMBL544554 1 4.35
CHEMBL543853 1 4.30
CHEMBL553998 1 4.22
CHEMBL553974 1 -
CHEMBL545486 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96680 Ki = 6.3 nM 8.20
CHEMBL262040 Ki = 8.7 nM 8.06
CHEMBL542185 Ki = 400.0 nM 6.40
CHEMBL94821 Ki = 2000.0 nM 5.70
CHEMBL554323 Ki = 3000.0 nM 5.52
CHEMBL545487 Ki = 6000.0 nM 5.22
CHEMBL554676 Ki = 8000.0 nM 5.10
CHEMBL542183 Ki = 10000.0 nM 5.00
CHEMBL541572 Ki = 12000.0 nM 4.92
CHEMBL543616 Ki = 14000.0 nM 4.85
CHEMBL544554 Ki = 45000.0 nM 4.35
CHEMBL543853 Ki = 50000.0 nM 4.30
CHEMBL553998 Ki = 60000.0 nM 4.22
CHEMBL553974 Ki = 350000.0 nM -
CHEMBL545486 Ki = 700000.0 nM -