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Assay Detail

CHEMBL752261

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Functional
Antagonistic activity towards NMDA receptor 1A/2B subtype was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype.
Tamiz AP, Whittemore ER, Schelkun RM, Yuen PW, Woodward RM, Cai SX, Weber E, Keana JF.
Bioorg Med Chem Lett (1998) 8 : 199 -200
PubMed 9871654 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 5.68 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL62130 1 6.77
CHEMBL61060 1 6.48
CHEMBL417389 1 6.17
CHEMBL60230 1 5.47
CHEMBL62181 1 5.13
CHEMBL60247 1 5.05
CHEMBL64286 N-P-COUMAROYL TYRAMINE 1 4.68
CHEMBL62044 1 -
CHEMBL417554 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL62130 IC50 = 170.0 nM 6.77
CHEMBL61060 IC50 = 330.0 nM 6.48
CHEMBL417389 IC50 = 680.0 nM 6.17
CHEMBL60230 IC50 = 3400.0 nM 5.47
CHEMBL62181 IC50 = 7400.0 nM 5.13
CHEMBL60247 IC50 = 9000.0 nM 5.05
CHEMBL64286 N-P-COUMAROYL TYRAMINE IC50 = 21000.0 nM 4.68
CHEMBL62044 IC50 > 300000.0 nM -
CHEMBL417554 IC50 > 300000.0 nM -