Assay Detail
Binding
CHEMBL752329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity in rat brain cortical membranes by the displacement of [3H]- DCKA at N-methyl-D-aspartate glutamate receptor 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.84 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123196 | — | — | 1 | 6.16 |
| CHEMBL333042 | — | — | 1 | 6.00 |
| CHEMBL91801 | — | — | 1 | 5.98 |
| CHEMBL123885 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123196 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL333042 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL91801 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL123885 | — | IC50 | = | 5900.0 | nM | 5.23 |