Assay Detail
Functional
CHEMBL752371
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50% inhibition against TNF-alpha release in N9 cells in the supernatant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | N9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.10 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51567 | — | — | 1 | 6.10 |
| CHEMBL142830 | — | — | 1 | - |
| CHEMBL140382 | — | — | 1 | - |
| CHEMBL335825 | — | — | 1 | - |
| CHEMBL143323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51567 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL142830 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL140382 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL335825 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL143323 | — | IC50 | > | 3000.0 | nM | - |