Assay Detail
Functional
CHEMBL752430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuronal sodium channel blocking activity by [14C]guanidinium flux assay
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2096682) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.92 | 5.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41306 | CNS-5161 | -1.0 | 1 | 5.76 |
| CHEMBL145968 | — | — | 3 | 4.08 |
| CHEMBL422495 | — | — | 1 | - |
| CHEMBL539841 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41306 | CNS-5161 | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL145968 | — | IC50 | = | 83100.0 | nM | 4.08 |
| CHEMBL145968 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL422495 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL539841 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL145968 | — | IC50 | > | 25000.0 | nM | - |